Search on: THROMBOSPONDIN 1 
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Descriptor English:   Thrombospondin 1 
Descriptor Spanish:   Trombospondina 1 
Descriptor Portuguese:   Trombospondina 1 
Synonyms English:   TSP-1  
Tree Number:   D12.776.395.550.895.800
D12.776.543.550.895.800
Definition English:   An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis. 
Indexing Annotation English:   a membrane glycoprotein
History Note English:   98; see THROMBOSPONDIN (NM) 1991-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33493 
Unique Identifier:   D019700 

Occurrence in VHL:
 

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